{"id":17948,"date":"2023-06-05T20:43:26","date_gmt":"2023-06-05T20:43:26","guid":{"rendered":"http:\/\/www.biosciencelublin.pl\/?page_id=17948"},"modified":"2023-06-11T22:49:58","modified_gmt":"2023-06-11T22:49:58","slug":"badania-in-vivo","status":"publish","type":"page","link":"https:\/\/www.biosciencelublin.pl\/index.php\/badania-in-vivo\/","title":{"rendered":"Badania in\u00a0vivo"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"17948\" class=\"elementor elementor-17948\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0f92cf6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0f92cf6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-674726a\" data-id=\"674726a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-957a595 elementor-widget elementor-widget-image\" data-id=\"957a595\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 24-06-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"525\" height=\"756\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-711x1024.webp\" class=\"attachment-large size-large wp-image-17882\" alt=\"\" srcset=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-711x1024.webp 711w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-208x300.webp 208w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-768x1107.webp 768w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-1066x1536.webp 1066w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-1421x2048.webp 1421w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-scaled.webp 1776w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7a7c16d\" data-id=\"7a7c16d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-35c777f elementor-widget elementor-widget-section-title\" data-id=\"35c777f\" data-element_type=\"widget\" data-widget_type=\"section-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"pt-section pt-style-1 text-left\">\r\n\t\t\r\n   \t\t \r\n   \t\t<span class=\"pt-section-sub-title\">BADANIA IN VIVO<\/span>\r\n   \t   \t\t\t   <h5 class=\"pt-section-title\" >Ocena toksyczno\u015bci nowych zwi\u0105zk\u00f3w<\/h5>\r\n\t\t\t\r\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f301f1 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"6f301f1\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/www.biosciencelublin.pl\/wp-content\/plugins\/elementor\/assets\/css\/widget-icon-box.min.css\">\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 512 512\" width=\"512\"><g><path d=\"m386.796 263.522h55.911c4.15 0 7.514-3.364 7.518-7.516.063-68.536-37.837-134.224-97.192-168.438-3.594-2.073-8.189-.839-10.263 2.757l-27.963 48.462c-36.498-18.453-81.402-18.455-117.905 0l-27.948-48.436c-2.664-3.755-6.087-4.673-10.27-2.753-59.331 34.275-97.137 99.809-97.201 168.395.427 4.588 2.933 7.098 7.518 7.529h55.909c.788 14.008 3.78 27.668 8.925 40.706 1.526 3.864 5.895 5.762 9.754 4.233 3.862-1.526 5.757-5.895 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69.876-163.849 229.573-93.93 350.752 69.834 121.006 229.442 163.944 350.549 93.986 74.183-42.857 121.94-119.564 127.751-205.19.28-4.145-2.85-7.733-6.992-8.014z\"><\/path><path d=\"m239.723 30.927c-34.201 2.43-66.706 12.421-96.612 29.695-52.159 30.129-89.469 78.779-105.057 136.988-15.588 58.207-7.589 119.007 22.523 171.196 61.334 106.284 201.641 144.029 308.017 82.572 106.183-61.336 143.901-201.825 82.523-308.184-37.095-64.281-103.449-106.195-177.493-112.122-4.138-.31-7.763 2.758-8.094 6.899s2.756 7.766 6.895 8.098c69.115 5.531 131.049 44.652 165.672 104.646 57.482 99.611 22.309 230.255-77.02 287.633-99.262 57.348-230.208 22.176-287.478-77.065-58.017-100.553-23.461-229.585 77.03-287.633 27.916-16.124 58.25-25.45 90.159-27.717 4.142-.295 7.261-3.892 6.966-8.037-.293-4.143-3.884-7.258-8.031-6.969z\"><\/path><path d=\"m275.965 289.043c18.367-10.821 24.806-34.365 14.149-52.835-10.546-18.275-34.54-24.708-52.804-14.157-18.265 10.55-24.665 34.544-14.149 52.834 10.157 17.667 32.282 26.249 52.804 14.158zm-31.137-53.963c11.089-5.983 25.652-2.809 32.265 8.65 6.512 11.286 2.633 25.768-8.645 32.284-11.28 6.515-26.044 2.797-32.265-8.651-4.722-8.689-4.722-25.071 8.645-32.283z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tTest ostrej toksyczno\u015bci zarodk\u00f3w rybich (Fish Embryo Acute Toxicity, FET)\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-294a540 elementor-widget elementor-widget-text-editor\" data-id=\"294a540\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 24-06-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Metoda badawcza opisana w\u00a0wytycznych OECD maj\u0105ca na\u00a0celu okre\u015blenie toksyczno\u015bci badanych zwi\u0105zk\u00f3w na\u00a0stadium embrionalne Danio rerio.<br \/><br \/><i>OECD (2013), Test No. 236: Fish Embryo Acute Toxicity (FET) Test, OECD Guidelines for the Testing of Chemicals, Section 2, OECD Publishing, Paris<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-47c2019 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"47c2019\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b96da0b\" data-id=\"b96da0b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9ab2bb6 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"9ab2bb6\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 512 512\" width=\"512\"><g><path d=\"m386.796 263.522h55.911c4.15 0 7.514-3.364 7.518-7.516.063-68.536-37.837-134.224-97.192-168.438-3.594-2.073-8.189-.839-10.263 2.757l-27.963 48.462c-36.498-18.453-81.402-18.455-117.905 0l-27.948-48.436c-2.664-3.755-6.087-4.673-10.27-2.753-59.331 34.275-97.137 99.809-97.201 168.395.427 4.588 2.933 7.098 7.518 7.529h55.909c.788 14.008 3.78 27.668 8.925 40.706 1.526 3.864 5.895 5.762 9.754 4.233 3.862-1.526 5.757-5.895 4.232-9.76-4.448-11.271-7.078-23.074-7.847-35.18h53.477c4.604-.436 7.11-2.96 7.518-7.569-.123-19.688 10.28-38.17 27.15-48.234 3.531-2.106 4.716-6.66 2.661-10.222l-26.346-45.658c31.905-15.833 70.935-15.835 102.844 0l-25.946 44.965c-1.926 4.215-.991 7.65 2.805 10.306 17.358 9.842 28.337 28.867 28.175 48.829.401 4.617 2.907 7.145 7.518 7.583h51.905c-2.382 37.115-22.26 69.544-51.448 89.095l-26.333-45.637c-2.055-3.561-6.589-4.813-10.178-2.805-17.147 9.586-38.344 9.359-55.323-.591-4.193-1.951-7.63-1.041-10.31 2.73l-26.784 46.418c-10.787-7.232-20.436-16.356-28.524-27.161-2.489-3.325-7.201-4.001-10.524-1.511-3.323 2.491-3.999 7.205-1.51 10.53 9.335 12.47 20.511 22.957 33.019 31.208l-27.901 48.354c-1.92 4.189-1 7.616 2.758 10.28 59.595 34.352 134.767 34.388 194.35-.031 3.596-2.077 4.828-6.678 2.752-10.276l-27.96-48.457c33.663-22.19 56.555-59.472 58.977-102.145zm-227.027-158.996 24.122 41.805c-33.667 22.191-56.559 59.474-58.981 102.146h-48.227c2.524-58.536 33.713-112.572 83.086-143.951zm54.477 94.412c-15.759 11.838-25.951 29.904-27.955 49.539h-46.318c2.382-37.115 22.26-69.544 51.448-89.095zm137.709-94.443c49.099 31.153 80.665 85.861 83.08 143.982h-48.24c-2.422-42.672-25.314-79.955-58.981-102.146zm-54.021 93.62 22.35-38.733c29.188 19.551 49.066 51.98 51.448 89.095h-44.737c-1.725-22.818-15.508-43.379-29.061-50.362zm-70.351 121.923c17.996 8.081 38.729 8.283 56.855.547l22.837 39.577c-31.864 15.813-71.005 15.873-102.905.107zm111.332 94.958c-51.846 27.094-114.21 27.1-166.135.021l24.051-41.682c36.487 18.378 81.527 18.305 117.975-.122z\"><\/path><path d=\"m504.921 265.165c-4.147-.291-7.729 2.849-8.01 6.996-5.47 80.616-50.43 152.833-120.267 193.179-115.355 66.637-263.397 26.944-330.01-88.479-66.596-115.423-26.928-263.549 88.428-330.2 115.356-66.635 263.397-26.944 330.01 88.479 18.794 32.569 29.529 67.97 31.907 105.222.265 4.145 3.832 7.308 7.982 7.027 4.144-.264 7.288-3.841 7.024-7.987-2.527-39.582-13.93-77.192-33.891-111.785-69.836-121.008-229.441-163.943-350.551-93.986-120.936 69.876-163.849 229.573-93.93 350.752 69.834 121.006 229.442 163.944 350.549 93.986 74.183-42.857 121.94-119.564 127.751-205.19.28-4.145-2.85-7.733-6.992-8.014z\"><\/path><path d=\"m239.723 30.927c-34.201 2.43-66.706 12.421-96.612 29.695-52.159 30.129-89.469 78.779-105.057 136.988-15.588 58.207-7.589 119.007 22.523 171.196 61.334 106.284 201.641 144.029 308.017 82.572 106.183-61.336 143.901-201.825 82.523-308.184-37.095-64.281-103.449-106.195-177.493-112.122-4.138-.31-7.763 2.758-8.094 6.899s2.756 7.766 6.895 8.098c69.115 5.531 131.049 44.652 165.672 104.646 57.482 99.611 22.309 230.255-77.02 287.633-99.262 57.348-230.208 22.176-287.478-77.065-58.017-100.553-23.461-229.585 77.03-287.633 27.916-16.124 58.25-25.45 90.159-27.717 4.142-.295 7.261-3.892 6.966-8.037-.293-4.143-3.884-7.258-8.031-6.969z\"><\/path><path d=\"m275.965 289.043c18.367-10.821 24.806-34.365 14.149-52.835-10.546-18.275-34.54-24.708-52.804-14.157-18.265 10.55-24.665 34.544-14.149 52.834 10.157 17.667 32.282 26.249 52.804 14.158zm-31.137-53.963c11.089-5.983 25.652-2.809 32.265 8.65 6.512 11.286 2.633 25.768-8.645 32.284-11.28 6.515-26.044 2.797-32.265-8.651-4.722-8.689-4.722-25.071 8.645-32.283z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tTesty toksyczno\u015bci rozwojowej (kardiotoksyczno\u015b\u0107, hepatotoksyczno\u015b\u0107, neurotoksyczno\u015b\u0107)\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6be5a4e elementor-widget elementor-widget-text-editor\" data-id=\"6be5a4e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Metoda badawcza opisana w\u00a0wytycznych OECD maj\u0105ca na\u00a0celu okre\u015blenie wp\u0142ywu badanych substancji na\u00a0powstawanie deformacji rozwojowych embrion\u00f3w Danio rerio.<br \/><br \/><i>Kurach L, Ch\u0142opa\u015b-Konowa\u0142ek A, Budzy\u0144ska B, Zawadzki M, Szpot P, Boguszewska-Czubara A. Etazene induces developmental toxicity in\u00a0vivo Danio rerio and in\u00a0silico studies of new synthetic opioid derivative. Sci Rep 2021 Dec 20;11(1):24269, doi: 10.1038\/s41598-021-03804-9.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8e08e25\" data-id=\"8e08e25\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-99d114a elementor-widget elementor-widget-image\" data-id=\"99d114a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"525\" height=\"933\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/science-technician-ppe-suit-using-micropipette-petri-dish-working-research-laboratory-analysing-blood-sample-team-examining-virus-evolution-vaccine-development-against-covid19-576x1024.webp\" 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elementor-top-section elementor-element elementor-element-34b5add elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34b5add\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9ab878f\" data-id=\"9ab878f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8ef1a7d elementor-widget elementor-widget-image\" data-id=\"8ef1a7d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"525\" height=\"788\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-682x1024.webp\" class=\"attachment-large size-large wp-image-18155\" alt=\"\" srcset=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-682x1024.webp 682w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-200x300.webp 200w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-768x1152.webp 768w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-1024x1536.webp 1024w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-1365x2048.webp 1365w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/woman-with-mask-microscope-scaled.webp 1706w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-73e7b1b\" data-id=\"73e7b1b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f6d8405 elementor-widget elementor-widget-section-title\" data-id=\"f6d8405\" data-element_type=\"widget\" data-widget_type=\"section-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"pt-section pt-style-1 text-left\">\r\n\t\t\r\n   \t\t \r\n   \t\t<span class=\"pt-section-sub-title\">BADANIA IN VIVO<\/span>\r\n   \t   \t\t\t   <h5 class=\"pt-section-title\" >Wp\u0142yw badanych zwi\u0105zk\u00f3w na aktywno\u015b\u0107 o\u015brodkowego uk\u0142adu nerwowego<\/h5>\r\n\t\t\t\r\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0435c8 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"a0435c8\" 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3.897 0 7.687-4.019 7.508-7.86-.814-17.391 5.961-34.647 17.679-45.034 18.504-16.404 50.331-11.045 60.614 12.251 17.182 38.964 26.604 81.482 27.715 124.038-20.425-4.569-43.072 6.387-52.377 24.866-1.866 3.704-.375 8.219 3.33 10.085 3.82 1.751 7.182.641 10.084-3.33 6.877-13.656 24.102-21.055 38.961-16.042-.39 11.69-1.766 23.329-4.104 34.692-.836 4.062 1.779 8.033 5.842 8.869 3.765.747 6.721-1.2 8.869-5.842 2.683-13.029 5.138-29.323 4.524-42.98z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tOcena proces\u00f3w pami\u0119ciowych, m.in.\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d3c425 elementor-widget elementor-widget-text-editor\" data-id=\"3d3c425\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"icon-box-description\">&#8211; Test biernego unikania &#8211; badane zwierz\u0119 (mysz, szczur) uczy si\u0119 unika\u0107 bod\u017aca awersyjnego, poprzez zahamowanie naturalnej sk\u0142onno\u015bci do\u00a0przebywania w\u00a0ciemnych pomieszczeniach.<\/p><p>&#8211; Test rozpoznawania nowego obiektu (ang. Novel Object Recognition Task; NOR) jest on\u00a0oparty na\u00a0naturalnej tendencji do\u00a0eksploracji nowych obiekt\u00f3w.<\/p><p><i>Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ. Using mice to\u00a0model Alzheimer&#8217;s dementia: an overview of the clinical disease and the preclinical behavioral changes in\u00a010 mouse models. Front Genet. 2014;5:88. Published 2014 Apr 23. doi:10.3389\/fgene.2014.00088<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6960d1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6960d1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-da07ec3\" data-id=\"da07ec3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-66ea16c elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"66ea16c\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-cloud-rain\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tOcena zachowa\u0144 depresyjnych m.in. \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b714d92 elementor-widget elementor-widget-text-editor\" data-id=\"b714d92\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Test zawieszenia za\u00a0ogon polega na\u00a0poddaniu gryzonia kr\u00f3tkotrwa\u0142emu, stresowi zwi\u0105zanemu z\u00a0zawieszeniem za\u00a0ogon i\u00a0ocenie zachowanie aktywnego i\u00a0pasywnego.<br \/><br \/>&#8211; Test wymuszonego p\u0142ywania &#8211; polega na\u00a0ocenie zachowania aktywnego (p\u0142ywanie i\u00a0wspinanie) lub pasywnego (bezruch), gdy\u00a0gryzonie s\u0105\u00a0umieszczane w\u00a0aparacie wype\u0142nionym wod\u0105.<br \/><br \/><i>Cryan JF, Mombereau C, Vassout A. The tail suspension test as\u00a0a\u00a0model for assessing antidepressant activity: review of pharmacological and genetic studies in\u00a0mice. Neurosci Biobehav Rev. 2005;29(4-5):571-625.<br \/><br \/>Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in\u00a0mice: a\u00a0review of antidepressant activity. Psychopharmacology (Berl). 2005 Jan;177(3):245-55<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-72c7518\" data-id=\"72c7518\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08218d3 elementor-widget elementor-widget-image\" data-id=\"08218d3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"787\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-683x1024.webp\" class=\"attachment-large size-large wp-image-18159\" alt=\"\" srcset=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-683x1024.webp 683w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-200x300.webp 200w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-768x1152.webp 768w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-1024x1536.webp 1024w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-1365x2048.webp 1365w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/work-laminar-box-scaled.webp 1707w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4075c4f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4075c4f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e759b82\" data-id=\"e759b82\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08f4c83 elementor-widget elementor-widget-image\" data-id=\"08f4c83\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"721\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/scientific-chemist-doctor-analyzing-virus-disease-developing-infection-treatment-746x1024.webp\" class=\"attachment-large size-large wp-image-18166\" alt=\"\" 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https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/scientific-chemist-doctor-analyzing-virus-disease-developing-infection-treatment-scaled.webp 1864w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ea624f9\" data-id=\"ea624f9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2843359 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"2843359\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-flushed\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tOcena zachowa\u0144 l\u0119kowych m.in:\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2f64fd elementor-widget elementor-widget-text-editor\" data-id=\"c2f64fd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Podwy\u017cszony labirynt krzy\u017cowy sk\u0142ada si\u0119 z\u00a0czterech ramion (dw\u00f3ch otwartych i\u00a0dw\u00f3ch zamkni\u0119tych), kt\u00f3re s\u0105\u00a0u\u0142o\u017cone w\u00a0kszta\u0142t plusa. Zasada testu oparta jest na\u00a0naturalnej niech\u0119ci zwierz\u0105t do\u00a0otwartych przestrzeni.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19229173\/\" target=\"_blank\" rel=\"noopener\">Komada M, Takao K, Miyakawa T. Elevated plus maze for mice. J Vis Exp. 2008 Dec 22;(22):1088.<\/a><\/p><div id=\"simple-translate\" class=\"simple-translate-system-theme\"><div>\u00a0<\/div><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-427d2a7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"427d2a7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0513884\" data-id=\"0513884\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa2ff52 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"aa2ff52\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 512 512\" width=\"512\"><g><path d=\"m437.02 74.98c-48.353-48.351-112.64-74.98-181.02-74.98s-132.667 26.629-181.02 74.98c-48.351 48.353-74.98 112.64-74.98 181.02s26.629 132.667 74.98 181.02c48.353 48.351 112.64 74.98 181.02 74.98s132.667-26.629 181.02-74.98c48.351-48.353 74.98-112.64 74.98-181.02s-26.629-132.667-74.98-181.02zm-21.214 340.826c-42.686 42.686-99.439 66.194-159.806 66.194s-117.12-23.508-159.806-66.194-66.194-99.439-66.194-159.806 23.508-117.12 66.194-159.806 99.439-66.194 159.806-66.194 117.12 23.508 159.806 66.194 66.194 99.439 66.194 159.806-23.508 117.12-66.194 159.806z\"><\/path><path d=\"m268.62 159.17c8.139-16.141 12.265-33.539 12.265-51.713 0-18.175-4.126-35.574-12.265-51.713l-26.787 13.506c6.006 11.912 9.052 24.767 9.052 38.207 0 13.439-3.046 26.294-9.052 38.207z\"><\/path><path d=\"m359.221 100.704c-8.139 16.14-12.265 33.539-12.265 51.713s4.126 35.573 12.265 51.713l26.787-13.507c-6.006-11.913-9.052-24.767-9.052-38.207s3.046-26.294 9.052-38.207z\"><\/path><path d=\"m246.827 326.402c-9.503 9.502-20.746 16.438-33.417 20.615l9.391 28.492c17.169-5.659 32.39-15.043 45.239-27.894 12.851-12.851 22.235-28.071 27.895-45.239l-28.492-9.393c-4.177 12.673-11.114 23.916-20.616 33.419z\"><\/path><path d=\"m357.513 298.269 9.391-28.492c-12.672-4.177-23.915-11.113-33.417-20.615-9.503-9.502-16.438-20.745-20.615-33.417l-28.492 9.391c5.658 17.169 15.044 32.39 27.895 45.24 12.848 12.849 28.069 22.234 45.238 27.893z\"><\/path><path d=\"m163.491 273.627c-11.915 6.007-24.77 9.053-38.207 9.053-13.438 0-26.293-3.046-38.206-9.053l-13.508 26.788c16.142 8.139 33.54 12.266 51.714 12.266 18.172 0 35.571-4.126 51.713-12.265z\"><\/path><path d=\"m329.21 370.933c-12.851 12.851-22.235 28.072-27.894 45.24l28.492 9.391c4.176-12.671 11.112-23.915 20.614-33.417 9.503-9.502 20.746-16.438 33.418-20.615l-9.391-28.492c-17.168 5.658-32.388 15.043-45.239 27.893z\"><\/path><path d=\"m146.553 227.833c16.142 8.139 33.54 12.266 51.714 12.266s35.572-4.126 51.714-12.266l-13.508-26.787c-11.913 6.007-24.768 9.053-38.206 9.053s-26.293-3.046-38.206-9.053z\"><\/path><path d=\"m434.559 219.725-26.787 13.507c6.007 11.914 9.053 24.768 9.053 38.207 0 13.438-3.046 26.293-9.053 38.207l26.787 13.507c8.139-16.142 12.266-33.541 12.266-51.713-.001-18.175-4.128-35.574-12.266-51.715z\"><\/path><path d=\"m141.521 155.486c9.503-9.503 20.746-16.438 33.418-20.615l-9.391-28.492c-17.169 5.658-32.39 15.043-45.24 27.894-12.851 12.851-22.235 28.072-27.894 45.24l28.492 9.39c4.177-12.671 11.114-23.914 20.615-33.417z\"><\/path><path d=\"m168.769 359.48-28.492 9.391c5.658 17.167 15.043 32.389 27.894 45.24 12.85 12.85 28.07 22.235 45.24 27.894l9.391-28.492c-12.673-4.177-23.916-11.112-33.418-20.615-9.503-9.503-16.44-20.746-20.615-33.418z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tOcena dzia\u0142ania przeciwdrgawkowego\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5913864 elementor-widget elementor-widget-text-editor\" data-id=\"5913864\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Danio pr\u0119gowany jest atrakcyjnym modelem padaczki in\u00a0vivo. Larwy danio pr\u0119gowanego wystawione na\u00a0dzia\u0142anie pentylenotetrazolu (PTZ) wykazuj\u0105 zwi\u0119kszon\u0105 aktywno\u015b\u0107 lokomotoryczn\u0105, zachowanie przypominaj\u0105ce drgawki i\u00a0aktywno\u015b\u0107 bioelektryczn\u0105 m\u00f3zgu przypominaj\u0105c\u0105 wy\u0142adowania obserwowane w\u00a0przebiegu ataku padaczkowego. Leki o\u00a0aktywno\u015bci przeciwpadaczkowe hamuj\u0105 wzrost aktywno\u015bci lokomotorycznej larw indukowanej PTZ.<br \/><br \/><i>Afrikanova T, Serruys AS, Buenafe OE, et\u00a0al.\u00a0Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to\u00a0antiepileptic drugs. PLoS One. 2013;8(1):e54166.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-01f368d\" data-id=\"01f368d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d59e98 elementor-widget elementor-widget-image\" data-id=\"7d59e98\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"525\" height=\"756\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-blurry-scientist-working-with-glass-slide-711x1024.webp\" class=\"attachment-large size-large wp-image-17882\" alt=\"\" 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https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/science-laboratory-equipment-test-tube-with-blood-healthcare-development-chemical-dripping-pipe-with-glass-flask-analysis-biochemistry-lab-clinic-professional-instruments-scaled.webp 1707w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-15a1ebf\" data-id=\"15a1ebf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c2b641e elementor-widget elementor-widget-section-title\" data-id=\"c2b641e\" data-element_type=\"widget\" data-widget_type=\"section-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"pt-section pt-style-1 text-left\">\r\n\t\t\r\n   \t\t \r\n   \t\t<span class=\"pt-section-sub-title\">BADANIA IN VIVO<\/span>\r\n   \t   \t\t\t   <h5 class=\"pt-section-title\" >Modele chor\u00f3b<\/h5>\r\n\t\t\t\r\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b116a57 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"b116a57\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 512 512\" width=\"512\"><g><path d=\"m463.3 369.609c-3.886-1.455-8.212.514-9.667 4.398-4.566 12.19-10.28 23.783-16.99 34.634-14.34-37.7-59.597-55.729-95.936-37.89-3.724 1.828-5.26 6.328-3.432 10.051s6.33 5.26 10.05 3.432c32.192-15.804 72.565 4.987 78.163 40.585-10.003 13.058-21.557 24.738-34.333 34.725-15.211-5.872-23.825-22.481-19.415-38.532 1.098-4-1.254-8.132-5.253-9.231-4.002-1.098-8.132 1.254-9.231 5.252-5.61 20.424 3.155 41.462 20.14 52.303-14.103 9.105-29.398 16.268-45.517 21.134-28.269 11.259-67.971 8.656-67.971-32.302v-81.897c2.509-19.275 19.034-34.209 38.981-34.209 4.148 0 7.51-3.362 7.51-7.51s-3.362-7.51-7.51-7.51c-15.276 0-29.1 6.338-38.981 16.521v-44.823c0-4.147-3.362-7.51-7.51-7.51-.027 0-.053.001-.08.001s-.053-.001-.08-.001c-4.148 0-7.51 3.362-7.51 7.51v109.345c-9.881-10.184-23.704-16.521-38.981-16.521-4.148 0-7.51 3.362-7.51 7.51s3.362 7.51 7.51 7.51c19.946 0 36.47 14.933 38.981 34.206v17.378c0 40.958-39.703 43.562-67.972 32.302-16.276-4.913-31.545-12.081-45.535-21.122 16.998-10.837 25.772-31.884 20.16-52.315-1.099-3.998-5.233-6.349-9.231-5.252-3.999 1.099-6.351 5.231-5.253 9.231 4.41 16.053-4.207 32.665-19.422 38.534-12.838-10.064-24.358-21.806-34.304-34.867 5.655-35.353 45.855-56.295 78.14-40.446 3.721 1.829 8.222.291 10.05-3.432s.291-8.223-3.432-10.051c-36.277-17.812-81.463.124-95.872 37.724-17.957-29.171-28.693-63.409-29.916-99.512 14.858-5.012 32.082 2.388 38.959 16.043 2.903 3.971 6.264 5.081 10.084 3.33 3.705-1.866 5.195-6.381 3.33-10.085-9.305-18.48-31.953-29.435-52.377-24.866.56-21.429 3.185-42.817 7.885-63.731.909-4.046-1.633-8.064-5.679-8.974-4.054-.911-7.918 1.669-8.975 5.68-30.706 116.549 16.733 242.171 137.049 278.49 28.863 10.525 61.745 13.126 79.902-18.379 18.157 31.504 51.04 28.904 79.902 18.378 60.745-18.339 109.376-66.576 131.477-125.573 1.455-3.883-.514-8.211-4.398-9.666z\"><\/path><path d=\"m102.574 193.844c-4.008-1.071-8.125 1.304-9.198 5.31-10.94 40.819 18.212 82.913 60.063 87.394-3.252 14.322-16.087 25.046-31.378 25.046-4.148 0-7.51 3.362-7.51 7.51s3.362 7.51 7.51 7.51c23.621 0 43.243-17.443 46.665-40.124 27.677-3.194 52.113-24.316 59.328-51.248 1.074-4.006-1.303-8.124-5.31-9.198-4.008-1.074-8.125 1.304-9.198 5.311-18.068 67.431-124.436 41.742-105.664-28.312 1.075-4.007-1.302-8.126-5.308-9.199z\"><\/path><path d=\"m366.077 270.03c-28.6 7.665-59.281-9.912-66.988-38.675-1.073-4.007-5.189-6.381-9.198-5.311-4.006 1.074-6.383 5.191-5.31 9.198 7.223 26.961 31.616 48.052 59.328 51.249 3.422 22.681 23.045 40.124 46.665 40.124 4.148 0 7.51-3.362 7.51-7.51 0-4.147-3.362-7.51-7.51-7.51-15.292 0-28.126-10.724-31.378-25.046 41.851-4.481 71.003-46.575 60.063-87.394-1.073-4.006-5.189-6.381-9.198-5.31-4.006 1.074-6.383 5.192-5.31 9.198 7.675 28.632-10.347 59.397-38.674 66.987z\"><\/path><path d=\"m481.626 303.704c.359-48.038-9.723-96.481-29.1-140.42-6.098-13.812-17.618-24.033-31.649-28.433 7.044-42.184-30.431-70.525-53.342-87.848-3.115-2.355-47.325-34.344-68.32-44.519-14.702-7.132-34.253 2.145-42.897 14.457-8.643-12.313-28.194-21.589-42.897-14.457-20.994 10.175-65.204 42.164-68.32 44.519-22.911 17.323-60.386 45.664-53.342 87.848-14.031 4.4-25.551 14.621-31.65 28.437-4.429 10.044-8.407 20.411-11.828 30.813-1.296 3.94.849 8.185 4.788 9.48 3.945 1.295 8.185-.849 9.48-4.788 3.268-9.94 7.071-19.847 11.301-29.442 10.259-23.241 42.172-28.604 60.615-12.254 11.718 10.388 18.493 27.643 17.679 45.034-.18 3.841 3.611 7.86 7.508 7.86 3.986 0 7.307-3.135 7.496-7.159 1.6-34.227-23.192-72.106-60.576-70.516-5.426-33.247 25.015-56.264 47.587-73.332 2.455-1.856 4.808-3.636 6.98-5.332 16.575 1.282 29.67 15.18 29.67 32.079 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-19.755-12.201-36.714-29.463-43.737 13.617-9.787 28.034-18.404 43.028-25.712 15.4-4.213 29.333 9.113 29.333 24.373v115.921c-22.468 3.606-39.689 23.128-39.689 46.597 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-15.158 10.536-27.9 24.669-31.29v94.126c0 4.147 3.362 7.51 7.51 7.51.027 0 .053-.001.08-.001s.053.001.08.001c4.148 0 7.51-3.362 7.51-7.51v-156.333c14.133 3.39 24.669 16.133 24.669 31.29 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-23.469-17.22-42.991-39.689-46.597v-53.715c0-15.26 13.933-28.586 29.333-24.373 14.994 7.308 29.411 15.925 43.028 25.712-17.262 7.024-29.463 23.982-29.463 43.737 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-16.899 13.095-30.796 29.67-32.079 2.171 1.697 4.525 3.476 6.98 5.332 22.572 17.067 53.013 40.085 47.587 73.331-13.964-.595-27.2 4.095-37.857 13.543-15.034 13.327-23.74 35.158-22.72 56.975.189 4.024 3.509 7.16 7.496 7.159 3.897 0 7.687-4.019 7.508-7.86-.814-17.391 5.961-34.647 17.679-45.034 18.504-16.404 50.331-11.045 60.614 12.251 17.182 38.964 26.604 81.482 27.715 124.038-20.425-4.569-43.072 6.387-52.377 24.866-1.866 3.704-.375 8.219 3.33 10.085 3.82 1.751 7.182.641 10.084-3.33 6.877-13.656 24.102-21.055 38.961-16.042-.39 11.69-1.766 23.329-4.104 34.692-.836 4.062 1.779 8.033 5.842 8.869 3.765.747 6.721-1.2 8.869-5.842 2.683-13.029 5.138-29.323 4.524-42.98z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tModele chor\u00f3b neurodegeneracyjnych:\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da9a214 elementor-widget elementor-widget-text-editor\" data-id=\"da9a214\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Nasilenie proces\u00f3w starzenia m\u00f3zgu typu alzheimerowskiego u\u00a0gryzoni indukowane podaniem D-galaktozy.<br \/><br \/>&#8211; Rozw\u00f3j zmian zapalnych i\u00a0amyloidogenezy w\u00a0obr\u0119bie uk\u0142adu nerwowego gryzoni indukowane lipopolisacharydem jako model choroby Alzheimera.<br \/><br \/>&#8211; Indukowane podaniem 6-hydroksydopaminy uszkodzenie neuroprzeka\u017anictwa dopaminergicznego jako model choroby Parkinsona u\u00a0Danio rerio.<br \/><br \/><i>Zhao M, Tang X, Gong D, Xia P, Wang F, Xu S. Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in\u00a0D-Galactose-Induced Aging Mice via Activating PI3K\/Akt\/Nrf2 Signaling Pathway. Front Pharmacol. 2020;11:71.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-01a60d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"01a60d7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-58627de\" data-id=\"58627de\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-17cc17e elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"17cc17e\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 512 512\" width=\"512\"><g><path d=\"m463.3 369.609c-3.886-1.455-8.212.514-9.667 4.398-4.566 12.19-10.28 23.783-16.99 34.634-14.34-37.7-59.597-55.729-95.936-37.89-3.724 1.828-5.26 6.328-3.432 10.051s6.33 5.26 10.05 3.432c32.192-15.804 72.565 4.987 78.163 40.585-10.003 13.058-21.557 24.738-34.333 34.725-15.211-5.872-23.825-22.481-19.415-38.532 1.098-4-1.254-8.132-5.253-9.231-4.002-1.098-8.132 1.254-9.231 5.252-5.61 20.424 3.155 41.462 20.14 52.303-14.103 9.105-29.398 16.268-45.517 21.134-28.269 11.259-67.971 8.656-67.971-32.302v-81.897c2.509-19.275 19.034-34.209 38.981-34.209 4.148 0 7.51-3.362 7.51-7.51s-3.362-7.51-7.51-7.51c-15.276 0-29.1 6.338-38.981 16.521v-44.823c0-4.147-3.362-7.51-7.51-7.51-.027 0-.053.001-.08.001s-.053-.001-.08-.001c-4.148 0-7.51 3.362-7.51 7.51v109.345c-9.881-10.184-23.704-16.521-38.981-16.521-4.148 0-7.51 3.362-7.51 7.51s3.362 7.51 7.51 7.51c19.946 0 36.47 14.933 38.981 34.206v17.378c0 40.958-39.703 43.562-67.972 32.302-16.276-4.913-31.545-12.081-45.535-21.122 16.998-10.837 25.772-31.884 20.16-52.315-1.099-3.998-5.233-6.349-9.231-5.252-3.999 1.099-6.351 5.231-5.253 9.231 4.41 16.053-4.207 32.665-19.422 38.534-12.838-10.064-24.358-21.806-34.304-34.867 5.655-35.353 45.855-56.295 78.14-40.446 3.721 1.829 8.222.291 10.05-3.432s.291-8.223-3.432-10.051c-36.277-17.812-81.463.124-95.872 37.724-17.957-29.171-28.693-63.409-29.916-99.512 14.858-5.012 32.082 2.388 38.959 16.043 2.903 3.971 6.264 5.081 10.084 3.33 3.705-1.866 5.195-6.381 3.33-10.085-9.305-18.48-31.953-29.435-52.377-24.866.56-21.429 3.185-42.817 7.885-63.731.909-4.046-1.633-8.064-5.679-8.974-4.054-.911-7.918 1.669-8.975 5.68-30.706 116.549 16.733 242.171 137.049 278.49 28.863 10.525 61.745 13.126 79.902-18.379 18.157 31.504 51.04 28.904 79.902 18.378 60.745-18.339 109.376-66.576 131.477-125.573 1.455-3.883-.514-8.211-4.398-9.666z\"><\/path><path d=\"m102.574 193.844c-4.008-1.071-8.125 1.304-9.198 5.31-10.94 40.819 18.212 82.913 60.063 87.394-3.252 14.322-16.087 25.046-31.378 25.046-4.148 0-7.51 3.362-7.51 7.51s3.362 7.51 7.51 7.51c23.621 0 43.243-17.443 46.665-40.124 27.677-3.194 52.113-24.316 59.328-51.248 1.074-4.006-1.303-8.124-5.31-9.198-4.008-1.074-8.125 1.304-9.198 5.311-18.068 67.431-124.436 41.742-105.664-28.312 1.075-4.007-1.302-8.126-5.308-9.199z\"><\/path><path d=\"m366.077 270.03c-28.6 7.665-59.281-9.912-66.988-38.675-1.073-4.007-5.189-6.381-9.198-5.311-4.006 1.074-6.383 5.191-5.31 9.198 7.223 26.961 31.616 48.052 59.328 51.249 3.422 22.681 23.045 40.124 46.665 40.124 4.148 0 7.51-3.362 7.51-7.51 0-4.147-3.362-7.51-7.51-7.51-15.292 0-28.126-10.724-31.378-25.046 41.851-4.481 71.003-46.575 60.063-87.394-1.073-4.006-5.189-6.381-9.198-5.31-4.006 1.074-6.383 5.192-5.31 9.198 7.675 28.632-10.347 59.397-38.674 66.987z\"><\/path><path d=\"m481.626 303.704c.359-48.038-9.723-96.481-29.1-140.42-6.098-13.812-17.618-24.033-31.649-28.433 7.044-42.184-30.431-70.525-53.342-87.848-3.115-2.355-47.325-34.344-68.32-44.519-14.702-7.132-34.253 2.145-42.897 14.457-8.643-12.313-28.194-21.589-42.897-14.457-20.994 10.175-65.204 42.164-68.32 44.519-22.911 17.323-60.386 45.664-53.342 87.848-14.031 4.4-25.551 14.621-31.65 28.437-4.429 10.044-8.407 20.411-11.828 30.813-1.296 3.94.849 8.185 4.788 9.48 3.945 1.295 8.185-.849 9.48-4.788 3.268-9.94 7.071-19.847 11.301-29.442 10.259-23.241 42.172-28.604 60.615-12.254 11.718 10.388 18.493 27.643 17.679 45.034-.18 3.841 3.611 7.86 7.508 7.86 3.986 0 7.307-3.135 7.496-7.159 1.6-34.227-23.192-72.106-60.576-70.516-5.426-33.247 25.015-56.264 47.587-73.332 2.455-1.856 4.808-3.636 6.98-5.332 16.575 1.282 29.67 15.18 29.67 32.079 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-19.755-12.201-36.714-29.463-43.737 13.617-9.787 28.034-18.404 43.028-25.712 15.4-4.213 29.333 9.113 29.333 24.373v115.921c-22.468 3.606-39.689 23.128-39.689 46.597 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-15.158 10.536-27.9 24.669-31.29v94.126c0 4.147 3.362 7.51 7.51 7.51.027 0 .053-.001.08-.001s.053.001.08.001c4.148 0 7.51-3.362 7.51-7.51v-156.333c14.133 3.39 24.669 16.133 24.669 31.29 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-23.469-17.22-42.991-39.689-46.597v-53.715c0-15.26 13.933-28.586 29.333-24.373 14.994 7.308 29.411 15.925 43.028 25.712-17.262 7.024-29.463 23.982-29.463 43.737 0 4.148 3.362 7.51 7.51 7.51s7.51-3.362 7.51-7.51c0-16.899 13.095-30.796 29.67-32.079 2.171 1.697 4.525 3.476 6.98 5.332 22.572 17.067 53.013 40.085 47.587 73.331-13.964-.595-27.2 4.095-37.857 13.543-15.034 13.327-23.74 35.158-22.72 56.975.189 4.024 3.509 7.16 7.496 7.159 3.897 0 7.687-4.019 7.508-7.86-.814-17.391 5.961-34.647 17.679-45.034 18.504-16.404 50.331-11.045 60.614 12.251 17.182 38.964 26.604 81.482 27.715 124.038-20.425-4.569-43.072 6.387-52.377 24.866-1.866 3.704-.375 8.219 3.33 10.085 3.82 1.751 7.182.641 10.084-3.33 6.877-13.656 24.102-21.055 38.961-16.042-.39 11.69-1.766 23.329-4.104 34.692-.836 4.062 1.779 8.033 5.842 8.869 3.765.747 6.721-1.2 8.869-5.842 2.683-13.029 5.138-29.323 4.524-42.98z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tModele depresji i upo\u015bledzenia pami\u0119ci:\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8c0b55 elementor-widget elementor-widget-text-editor\" data-id=\"c8c0b55\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Przewlek\u0142y, \u0142agodny, nieprzewidywalny stres (chronic mild unpredictable stress) czyli zastosowanie d\u0142ugotrwa\u0142ego, niekontrolowanego i\u00a0nieprzewidywalnego stresu, indukuje zmiany definiowane jako zachowania depresyjne oraz\u00a0deficyty kognitywne.<br \/><br \/><i>Willner P.\u00a0The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiol Stress. 2016;6:78-93.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9da092c\" data-id=\"9da092c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a889cb4 elementor-widget elementor-widget-image\" data-id=\"a889cb4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"295\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-hand-holding-tube-1024x576.webp\" class=\"attachment-large size-large wp-image-17944\" alt=\"\" srcset=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/close-up-hand-holding-tube-1024x576.webp 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2.45c1.054 49.936-13.733 85.374-43.949 105.33zm58.986-103.135c11.008-15.018 19.217-17.663 24.504-18.318 8.306-1.029 17.814 2.475 28.817 6.531 17.915 6.604 39.76 14.654 69.747 9.43-5.843 40.13-23.45 77.827-49.137 104.68-16.53 17.28-35.484 31.862-54.812 42.169-22.227 11.853-44.06 17.719-64.924 17.454-8.459-.11-23.051-1.663-25.74-10.83-2.842-9.688 6.889-26.26 20.825-35.464 34.272-22.634 51.329-61.534 50.72-115.652z\"><\/path><path d=\"m341.898 376.797c12.406 0 22.5-10.093 22.5-22.499s-10.094-22.5-22.5-22.5-22.5 10.094-22.5 22.5 10.094 22.499 22.5 22.499zm0-29.999c4.136 0 7.5 3.364 7.5 7.5 0 4.135-3.364 7.499-7.5 7.499s-7.5-3.364-7.5-7.499c0-4.136 3.364-7.5 7.5-7.5z\"><\/path><path d=\"m353.597 92.696h15v15h-15z\"><\/path><path d=\"m383.597 107.697h15v15h-15z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tModele chor\u00f3b metabolicznych\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5159246 elementor-widget elementor-widget-text-editor\" data-id=\"5159246\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Cukrzyca typu 1 jest spowodowana autoimmunologicznym zniszczeniem kom\u00f3rek \u03b2 trzustki i\u00a0wynikaj\u0105cym z\u00a0tego brakiem produkcji insuliny wywo\u0142anym wstrzykni\u0119ciami streptozotocyny.<br \/><br \/>&#8211; Cukrzyca typu 2 jest wynikiem po\u0142\u0105czenia zar\u00f3wno insulinooporno\u015bci, jak i\u00a0niezdolno\u015bci kom\u00f3rek \u03b2 do\u00a0odpowiedniej kompensacji zwi\u0119kszonego uwalniania insuliny. Cukrzyca typu 2 jest wywo\u0142ywana przez\u00a0diet\u0119 wysokot\u0142uszczow\u0105 i\u00a0streptozotocyn\u0119 (HFD\/STZ)<br \/><br \/><i>Al-Awar A, Kupai K, Veszelka M, Sz\u0171cs G, Attieh Z, Murlasits Z, T\u00f6r\u00f6k S, P\u00f3sa A, Varga C. Experimental Diabetes Mellitus in\u00a0Different Animal Models. J Diabetes Res. 2016;2016:9051426<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e0316e4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e0316e4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ddc3a09\" data-id=\"ddc3a09\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e9eb69b elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"e9eb69b\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_1\" height=\"512\" viewBox=\"0 0 511.99 511.99\" width=\"512\"><g><path d=\"m324.199 426.475c-2.93-2.929-7.678-2.929-10.607 0-9.299 9.3-9.299 24.431 0 33.731 4.506 4.505 10.495 6.986 16.865 6.986 6.371 0 12.36-2.481 16.866-6.986 2.929-2.929 2.929-7.678 0-10.606-2.93-2.929-7.678-2.929-10.607 0-3.45 3.45-9.064 3.452-12.517 0-1.672-1.672-2.593-3.895-2.593-6.259 0-2.365.921-4.587 2.593-6.259 2.929-2.93 2.929-7.679 0-10.607z\"><\/path><path d=\"m273.266 233.095c3.896 1.377 8.187-.658 9.57-4.572 1.381-3.905-.666-8.19-4.572-9.571-13.522-4.78-22.608-17.635-22.608-31.987 0-4.142-3.358-7.5-7.5-7.5s-7.5 3.358-7.5 7.5c0 20.698 13.105 39.236 32.61 46.13z\"><\/path><path d=\"m479.335 418.719h-58.646c-27.062 0-50.855-18.257-57.861-44.398l-47.243-176.314c-4.302-16.058-12.789-30.759-24.544-42.514l-68.408-68.407c-2.929-2.929-7.678-2.929-10.606 0-2.929 2.929-2.929 7.678 0 10.606l68.407 68.407c9.896 9.896 17.041 22.272 20.663 35.79l47.243 176.314c8.759 32.687 38.511 55.516 72.35 55.516h58.646c6.443 0 11.685 5.242 11.685 11.685 0 4.798-2.581 9.269-6.736 11.667l-.687.397c-.475-1.115-1.071-2.185-1.785-3.187-5.91-8.31-16.382-11.726-26.055-8.5l-16.703 5.568c-3.93 1.31-6.053 5.558-4.743 9.487 1.311 3.93 5.556 6.053 9.487 4.744l16.703-5.568c3.37-1.127 7.026.066 9.088 2.965.433.607.419 1.214.331 1.616-.087.401-.326.956-.966 1.329l-6.441 3.719c-30.991 17.893-66.287 27.35-102.073 27.35h-39.093c-13.882 0-25.176-11.294-25.176-25.176v-40.149c0-13.316-5.186-25.835-14.602-35.251l-21.659-21.659c-1.936-1.935-3.854-3.941-5.701-5.963-2.795-3.057-7.538-3.271-10.596-.477s-3.271 7.538-.477 10.596c2 2.188 4.075 4.358 6.168 6.451l21.659 21.659c6.583 6.583 10.208 15.335 10.208 24.645v40.149c0 22.153 18.022 40.176 40.176 40.176h39.093c38.412 0 76.299-10.151 109.565-29.355 1.013-.585 19.562-11.294 21.778-12.573 8.781-5.069 14.236-14.518 14.236-24.658-.001-14.717-11.971-26.687-26.685-26.687z\"><\/path><path d=\"m206.13 244.915v-22.841c0-8.828-7.182-16.01-16.01-16.01h-8.934c-34.586 0-67.102-13.468-91.558-37.924l-68.657-68.658v-84.482h108.363l57.853 57.853c2.929 2.929 7.678 2.929 10.606 0 2.929-2.929 2.929-7.678 0-10.606l-59.803-59.804c-1.575-1.575-3.669-2.443-5.897-2.443h-117.781c-4.6 0-8.341 3.742-8.341 8.341v93.898c0 2.229.868 4.323 2.443 5.898l70.608 70.608c27.289 27.289 63.572 42.318 102.164 42.318h8.934c.557 0 1.01.453 1.01 1.01v22.841c0 36.809 10.204 72.831 29.51 104.173 2.176 3.532 6.799 4.621 10.319 2.452 3.526-2.172 4.625-6.792 2.452-10.319-17.847-28.974-27.281-62.276-27.281-96.305z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tModel nocycepcji\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bfded8d elementor-widget elementor-widget-text-editor\" data-id=\"bfded8d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>&#8211; Dzi\u0119ki szerokiej gamie narz\u0119dzi, kt\u00f3re s\u0105\u00a0dost\u0119pne do\u00a0bada\u0144 na\u00a0gryzoniach i\u00a0danio pr\u0119gowanym, modele te\u00a0mo\u017cna zastosowa\u0107 w\u00a0dziedzinie bada\u0144 nad\u00a0b\u00f3lem, w\u00a0obszarach podstawowych mechanizm\u00f3w b\u00f3lu, jak i\u00a0oceny dzia\u0142ania antynocyceptywnego nowych zwi\u0105zk\u00f3w, kt\u00f3re mog\u0105 zmieni\u0107 percepcj\u0119 b\u00f3lu.<br \/><br \/><i>Ellis LD, Berrue F, Morash M, Achenbach JC, Hill J, McDougall JJ. Comparison of cannabinoids with known analgesics using a\u00a0novel high throughput zebrafish larval model of nociception. Behav Brain Res. 2018 Jan 30;337:151-159.<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4258fa7\" data-id=\"4258fa7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-47b589a elementor-widget elementor-widget-image\" data-id=\"47b589a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"787\" src=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-683x1024.webp\" class=\"attachment-large size-large wp-image-18176\" alt=\"\" srcset=\"https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-683x1024.webp 683w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-200x300.webp 200w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-768x1152.webp 768w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-1024x1536.webp 1024w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-1365x2048.webp 1365w, https:\/\/www.biosciencelublin.pl\/wp-content\/uploads\/2023\/06\/still-life-arrangement-test-tubes-scaled.webp 1707w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>BADANIA IN VIVO Ocena toksyczno\u015bci nowych zwi\u0105zk\u00f3w Test ostrej toksyczno\u015bci zarodk\u00f3w rybich (Fish Embryo Acute Toxicity, FET) Metoda badawcza opisana w\u00a0wytycznych OECD maj\u0105ca na\u00a0celu okre\u015blenie toksyczno\u015bci badanych zwi\u0105zk\u00f3w na\u00a0stadium embrionalne Danio rerio. OECD (2013), Test No. 236: Fish Embryo Acute Toxicity (FET) Test, OECD Guidelines for the Testing of Chemicals, Section 2, OECD Publishing, Paris [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/pages\/17948"}],"collection":[{"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/comments?post=17948"}],"version-history":[{"count":119,"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/pages\/17948\/revisions"}],"predecessor-version":[{"id":18455,"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/pages\/17948\/revisions\/18455"}],"wp:attachment":[{"href":"https:\/\/www.biosciencelublin.pl\/index.php\/wp-json\/wp\/v2\/media?parent=17948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}